The above diagram shows the controversy concerning IGF-1. IGF-1 is both a Dr. Jekyll and Mr. Hyde when it comes to our well-being and longevity. On one hand we see that the IGF-1 axis encourages development, growth, and injury repair. This can give the appearance of vitality and youth. However, appearances can be deceiving. IGF-1…
Read MoreNF- kB is a central regulator in stress response. The NF- kB signaling pathway can be activated by numerous stimuli as listed in the blue boxes: In response to these different stimuli NF- kB transcriptionally regulates hundreds of genes, the generalized categories of which are listed in the red circles. NF-kB is a short name of…
Read MoreThe above diagram shows the locations of the Sirtuin family of proteins as they are found in the cell. Sirtuins are a family of seven proteins that regulate cellular health. The sirtuins are present in the mitochondria (Sirt 3,4,5) and in the cell nucleus (Sirt 1,6,7). The sirtuins represent one of the most important pathways…
Read MoreIn 1972, Easter Island, called Rapa Nui, famous for its Moai statues, offered a new wonder: the discovery of the drug rapamycin named after the island’s Polynesian name, Rapa Nui. Over the past three decades, rapamycin, which was isolated from soil bacteria, has been applied as an immuno-suppressor in a multitude of ways, including…
Read MoreAs a physician and scientist, I always like to put politics aside. I must give accolades to Operation Warp Speed. It is difficult for people outside the biomedical research circuit to grasp the magnitude of creating a working vaccine for any disease, within a year. To put that in perspective, the fastest vaccine development…
Read MoreThe above diagram depicts the various pillars of aging. Unfortunately, these causes of aging seem to gang-up on an individual. When we look at aging we need to look at “Hallmarks of Aging”. The next diagram is an excellent synopsis of Aging. It demonstrates what I call the upstream causes of aging. We can see…
Read MoreThere are four main longevity pathways identified in organisms including humans: 1. AMP-activated protein kinase (AMPK) pathway 2. mTOR Pathway 3. Sirtuin Pathway 4. Nuclear factor-kappa B (NF-kB) pathway. In this blog we would like first like to address the AMPK pathway. AMPK is an important aspect of the new field of bioenergetics. Although the…
Read MoreI am a huge fan of NAD+ supplementation. My family and I take an NAD supplement on a daily basis. In addition to that, we will occasionally take an Intravenous dose of NAD+. It is indisputable that as we age we absolutely need more NAD+ or we basically face an increasing assault by the ravages…
Read MoreThe three above supplements are extremely important for optimal health but unfortunately, we have problems with their absorption. We may diligently take them orally on a daily basis which certainly helps but many times that may not be sufficient. However, if we are able to supplement our daily oral doses with Intravenous applications then we…
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Oxidative stress is an imbalance between free radicals and antioxidants in your body. Free radicals are oxygen-containing molecules with an uneven number of electrons. The uneven number allows them to easily react with other molecules. Free radicals can cause large chain chemical reactions in your body because they react so readily with other molecules. These…
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