Dr. P’s Blogs

Above we can see what an actual cytokine “patchless patch” looks like. These patches are absolutely unique. They are the brainchild of Dr. Jo Serrentino. She has devoted a good portion of her life to the study of cytokines. I feel quite privileged to work with Dr. Jo Serrentino. She is my colleague, a mentor,…

(stem cells in a bottle is the pitch)   It seems in the last few weeks I have seen a number of patients that have consulted with me after they have been treated “Amniotic Stem Cells” but still continued to be symptomatic.  Occasionally, I will also see a patient who claims that they were treated…

This weekend I spent a whirlwind trip to Morocco. I left Miami Thursday night and was back Sunday night.  I was invited there to share information with a very interested medical community.  Their eagerness reminded me of myself when I began the journey into regenerative medicine over twelve years ago.  At that time, I was…

This is not a trick question. I can actually think of a few places but none fit the category better than a spinal disc does. Disc degeneration is about the cellular microenvironment more so than other areas. Like the moon the microenvironment inside the disc is very hostile on many different levels. The disc environment…

  The above diagram shows the difference between a normal cell and a cell which is in a senescent state.   A senescent cell is a cell that has stopped replicating. Although senescent cells can no longer replicate, they remain metabolically active and commonly adopt a pattern of secreting pro-inflammatory cytokines, the up-regulation of immune ligands,…

   BOSTON BIOLIFE MEETING The above pictures may be confusing to those who are history buffs. I am mentioning the Boston Biolife meeting yet I am showing pictures of Constitution Hall in Philadelphia. The simple reason for this was that the Boston Biolife Meeting was held in Philadelphia. This was the first time I gave…

ARE ALL PRPs THE SAME? WHAT ABOUT PRXP? In the Regenerative Medicine field, there has for some time been controversy concerning certain aspects of Platelet Rich Plasma or PRP as it is called. There seems to be a misconception in some circles that some components of a PRP are bad. There is a belief amongst…

The Boston Biolife Meeting Occasionally I am asked by some docs where I will be doing my next speaking engagement. I have tried to cut down on my international travel schedule. It will be creeping up in the fall with a few trips to Asia. In the meantime, I will try to stay local in…

Nitric oxide whose chemical symbol is NO may be one of the key players in the stem cell regenerative medicine world.  I call it one of the “holy grails” of stem cell therapy.  Nitric oxide is probably one of the most important signaling molecules in our body.  It has an effect on almost everything from…

STEM CELLS AND THE IMMUNE SYSTEM (PART 2)   In part one we have discussed various effects that the stem cells have upon the immune system.  Various stem cells will help in the release of certain type of immune cells.  Some of these cells will stimulate an immune response while other will diminish the immune…