The Institute of Regenerative Medicine is very different from most all of the entities out there that are performing Regenerative Medicine treatments. We are taking a multifaceted approach to our treatment of the patient. Our differences start from the very beginning.
Typically, when patients are treated they will be placed on a number of supplements. The supplement regimen has two main purposes.
First, we want to change the micro-environment that the cells reside in by reducing oxidative stress. Oxidative stress is caused by free radicals. Free radicals are Oxygen molecules which have a free electron. This free electron causes damage to the cells in many different ways including the cell’s DNA and its mitochondria which are the cell power houses. By using antioxidants and other nutrients we can overcome many of these problems and get the cells and the environment primed for the stem cells and other regenerative cells to do their best.
The second main purpose of the supplement regimen is to stimulate the bone marrow to increase the number of regenerative cells it releases into the circulation. Without these new cells from the bone marrow, our procedures are doomed to fail. These supplement regimens are proprietary and are based on years of experience, scientific studies, and the recommendations of our own staff of clinical nutritionists. We work with companies make supplements that are licensed by a university. One example of a supplement we utilize mimics the same effects as would be obtained with hyperbaric oxygen. Hyperbaric oxygen gets people better not by increasing oxygen to the tissue but by increasing the number of stem cells in the circulation. This comes from a regimen of using Nitric Oxide generators.
One tremendous difference between the Institute of Regenerative Medicine and other clinics is that the Institute believes that a symphony of cells should be used to provide the maximum chance of success. Many clinics use stem cells derived from either fat or bone marrow but few use both. Bone marrow and fat each have the advantages and disadvantages.
Fat tissue is a treasure trove of stem cells and other regenerative cells. The problem with fat is that it mainly has mesenchymal stem cells which we now know are not primary drivers of tissue regeneration. They are very important for preparing the environment for other stem cells to perform their work. They are very much like a Navy Seal strike team. They are “parachuted” (injected) into a hostile area and are typically not expected to survive. The other type of fat stem cell is a hematopoietic stem cell which is the true driver of tissue regeneration. The problem with the fat hematopoietic stem cells is that they are short-lived and not as efficient as other sources of similar types of stem cells. Using only fat with a PRP can in many, but not all instances lead to diminished success. The patient will still get better but probably not as much as he would with other methods.
Bone marrow, on the other hand, has much smaller numbers of mesenchymal stem cells but makes up for this deficiency by having large numbers of hematopoietic stem cells. These hematopoietic stem cells either transform themselves or coax other cells to accomplish repair and regeneration. As one can see when both fat and bone marrow are used tougher, it unleashes the true reparative powers of the regenerative cells including stem cells. Remember the mesenchymal and hematopoietic stem cells work as a team to achieve success together! Unlike many clinics, The Institute of Regenerative Medicine has no vested interest in utilizing one cell type over another. Our vested interest is to give our patients the best chance of success.
The Institute has propriety methods of increasing the effectiveness of both the PRP and Stem Cell injections. We know for instance that the “recipe” for the PRP is critical. Too much or too little platelets diminishes stem cell effectiveness. Also removing certain components such as White Blood Cells (WBCs) of the PRP can again limit stem cell effectiveness. The WBCs are instrumental in telling the stem cells where to go. They act as a homing mechanism for the stem cells. We also know that under the right circumstances the WBCs can be coaxed to produce growth factors that dramatically reduce inflammation.
One thing we do not stand for is resting on our laurels. The stem cell field is rapidly evolving and growing. In an ever-changing field, today’s cutting edge is tomorrow’s has been. New innovations are always cropping up. We go to great lengths to investigate these innovations and use those which we deem worthy. We are now using a very potent cell found in the circulating blood and bone marrow. We are calling this cell an Adult Pluripotent Stem Cell. We feel this cell may be very important in our Anti-aging regimens in addition to our musculoskeletal treatments.
Another new innovation is our use of growth factors. We have been using these growth factors for several years. These growth factors are called cytokines. Cytokines are a bedrock of our treatment protocols. We utilize them in a variety of fashions. They can be the difference between success and failure. One of the problems we face in regenerative procedures is that our PRP and stem cells many times lack the necessary cytokines to achieve success. We utilize cytokines in a variety of methods to achieve success. We have different formulas which are specific for specific conditions. When dealing with cytokines it is not just knowing which ones to use but also what dosages and combinations to utilize. We are looking forward to some exciting new methods of utilizing cytokines in the very near future.
We are now involved in the use of lasers that are used in a variety of different avenues. Lasers are taking on a significant importance in the stem cell arena. Lasers will stimulate the mitochondria of the cells to produce more ATP. One should think of the mitochondria as similar to the chloroplasts in plants. They convert light energy to chlorophyll. The mitochondria can do essentially the same thing converting light energy to ATP which powers the cells. Lasers may also become a bedrock of anti-aging protocols. They seem to stimulate certain substances that are known to slow down aging.
We are also one of the few Stem cell centers which employ the use of shock wave therapy. Shockwave therapy is becoming increasingly important in our regimens. Shockwave therapy works on a number of different levels. It can cause the release of various growth factors which will encourage healing. Very importantly, it will encourage stem cell homing to the area that the shock wave was performed. We have developed propriety regimens to use with the shockwave machines.
One of our newest discoveries is the Artholavage technique. This technique cleans out the inflammatory substances from a joint. We have discovered a method of producing a lubricant for the joint that seems much more effective than hyaluronic acid. This lubricant is called Lubricin. At the same time, the Artholavage enables us to disable the inflammatory cytokines found in a joint. The amazing aspect of Artholavage is that it takes about ten minutes to achieve the results. We feel that this is improving our overall results.
All in all The Institute of Regenerative Medicine is poised to take Regenerative cell treatments to the next level. There will definitely be more to come. Thanks Dr. P